Preheat oven to 350 degrees F
In a medium mixing bowl, mix ground turkey, bread crumbs, egg, apple, cranberries, salt, garlic powder, onion powder and sage. Mix well.
Cut the top off of the pumpkin. Leave enough space so that you can get your hand inside.
Remove the seeds and pulp
Spoon turkey mixture into the hallowed out pumpkin until it's full. Leave enough room to put the top of the pumpkin back on.
Place pumpkin in a shallow baking dish and bake for an hour.
Remove the top of the pumpkin and set aside.
Cook pumpkin for an additional 20 minutes until the pumpkin meat is soft. Turkey mixture should be at least 165 degrees F.
Remove the pumpkin and serve.